Medical disclaimer: GutVerdict summarizes what people say about supplements on Reddit. It is not medical advice, and nothing here is meant to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Talk to your doctor or pharmacist before starting a supplement, especially if you are pregnant, take medicines, or have a medical condition. New, severe or worsening symptoms (such as blood in the stool, weight loss, fever, or night-time symptoms) need a doctor, not a supplement. Full disclaimer.

Spore-based probiotics (Bacillus) vs Saccharomyces boulardii

On Reddit, owners rate Spore-based probiotics (Bacillus) higher overall (4.2 vs 4.0). Scores summarize self-reported experiences and are not evidence that either will work for you.

Spore-based probiotics (Bacillus)Saccharomyces boulardii
Typecapsulescapsules
GutVerdict score4.24.0
Owner sentiment3.93.6
Recommendations3.73.7
Tolerability4.84.8
Owner comments194478
Rated comments83177
Unwanted effects reported8%8%
Top praiseBloating & gas, Dose & timingDose & timing, Urgency & loose stools
Top complaintsSide effects, Bloating & gasSide effects, Urgency & loose stools

By symptom

ContextSpore-based probiotics (Bacillus)Saccharomyces boulardii
IBS-C & constipation16 of 17 positive16 of 21 positive
IBS-D & loose stools2 of 4 positive28 of 32 positive
Bloating & gas13 of 17 positive24 of 26 positive
SIBO30 of 38 positive65 of 87 positive
After antibiotics5 of 6 positive39 of 43 positive
Pain & cramping6 of 7 positive13 of 16 positive

What owners say about Spore-based probiotics (Bacillus)

4/5

“I started taking spore based probiotics lately because it's supposed to help with the health of the valve and it do believe it is helping.”

owner comment via r/SIBO · 2026-10-16 · 9 upvotes
2/5 Bloating & gas

“I have/had similar symptoms and tried all those probiotics including some fancy ones like HU58 spore based ones and etc, probiotics never helped (and probiotic food like kimchi and fermented stuff would give me insane gas and acne).”

owner comment via r/SIBO · 2026-09-02 · 8 upvotes
4/5

“bacillus coagulans has been really good for me and mine.”

owner comment via r/IBS · 2026-06-11 · 5 upvotes

Full Spore-based probiotics (Bacillus) page →

What owners say about Saccharomyces boulardii

4/5 Cost

“I've tolerated taking Florastor 3x a day during antibiotics.”

owner comment via r/SIBO · 2026-10-04 · 6 upvotes
1/5

“Boulardii followed by a month of daily lentils solved 3 years of gut imbalance for me.”

owner comment via r/Microbiome · 2026-09-28 · 12 upvotes
4/5

“Just added S Boulardii, which I previously tried and reacted to but now doing much better on it.”

owner comment via r/SIBO · 2026-05-15 · 10 upvotes

Full Saccharomyces boulardii page →

Talk to a doctor or pharmacist before switching or combining supplements, particularly if you take other medicines.