Illustration, not a product photo.
The 8-strain De Simone formulation sold as Visbiome (and formerly as VSL#3).
70 owner comments (31 with a clear rating) from r/IBS, r/Microbiome, r/SIBO, r/Constipation, November 2025 to October 2026. Top 50% of the 36 rated supplements.
Value is not rated: the example products differ too much in dose to compare cost fairly. How we score.
High-potency multi-strain (VSL#3 / Visbiome) is rated about average among the supplements we track: 3.7/5. Of 31 rated owner comments, 28 were positive, 1 mixed and 2 negative; 5 mention an unwanted effect. People talk most about cost and side effects.
Reddit comments are self-reported and unverified. They tell you what people noticed, not whether a supplement works or is safe for you.
Our probiotic strain guide compares Align, Culturelle and Florastor. Reddit owners also rank supplements by SIBO reports. There is a separate ranking of what people with bloating and gas rate highest.
Supplements can interact with medicines. Talk to a doctor or pharmacist first, especially if you are pregnant, take prescription medicine, or have red-flag symptoms. See supplement safety and interactions.
| Context | Rated owner comments | Positive | Negative | Unwanted effects |
|---|---|---|---|---|
| SIBO | 10 | 8 | 1 | 1 |
| After antibiotics | 9 | 8 | 0 | 0 |
| Bloating & gas | 8 | 6 | 1 | 2 |
| Pain & cramping | 8 | 6 | 1 | 1 |
| IBS-C & constipation | 6 | 5 | 1 | 1 |
| IBS-D & loose stools | 3 | 2 | 1 | 1 |
5/5 Fast-actingStool form“when i started vsl#3, which is basically the same formula, it was like a crime scene in the bathroom for a solid ten days.”
5/5“Visbiome is made for post antibiotic rebalance, I love them and have used it for years now without fail.”
4/5“I think its a great supplement and you can take it for a while and then do a high potency probiotic like vsl3, thats what ive done with good results”
2/5“I've only tried vsl 3 for 2 months now, without a clear improvement”
5/5 Cost“I take Visbiome probiotic. It is expensive but changed my life when I was having so much trouble. Only buy it from a place that keeps it refrigerated and keep it inside your refrigerator and not the door.”
4/5 Regularity“I am using vsl3 refrigerated probiotics.”
5/5 Cost“I also swear by VSL #3 personally, it’s expensive but this is the second time I’m taking it and it’s the second time it’s helped a lot.”
4/5“Mine was the same as well I tried VSL3, symprove etc etc and then what helped me were also basic ones :D You just need to hit that one -or mujltiple- strain that your gut needs, and you need to be consistent.”
4/5 Cost“Thankfully I haven’t needed to do that, but I have had positive experiences using the probiotics from Visbiome.”
4/5“I recently tried taking high doses of the probiotic VSL III and saw improvement in my symptoms as well as a significant improvement in some depression I’d been dealing with since COVID.”
4/5 Cost“I take Visbiome! A bit pricey, but I think they are great.”
4/5“I also started taking VSL #3 and it did get better, a lot better actually.”
4/5“I also just took some visbiome which is a probiotic.”
5/5“Boulardi, culturelle, occasional Visbiome) that worked wonders for me and started having two poops on a perfect schedule nearly every day (I'm still on the probiotic regimen, and it is helping restore things slowly again).”
4/5“The probiotics that have been helpful for me are the Visbiome probiotics (ordered directly from the manufacturer, they ship in temperature controlled packaging and the probiotics have to be kept refrigerated).”
5/5“That’s interesting…I take 2 packets of Visbiome (450 billion / packet) daily and it’s been a life saver.”
4/5 Cost“I got postpartum IBS and been taking vsl#3 it’s super expensive but I will say I’m slooooowly starting to feel better but my GI says it’s the best one”
4/5 Cost“Visbiome (De Simone Formulation, Formerly called VSL #3), more expensive but has published research studies backing it.”
4/5“I took Vivomixx and it worked somewhat, but as I stoped everything was bad again”
4/5“Eating whole foods, not eating in between meals, exercise, improved sleep, reducing stress, and Visbiome helped me a lot.”
4/5“I was on Visbiome (3-4 capsules/day) for a month.”
4/5 Bloating & gasSide effects“Visbiome greatly improved my BO but gave me bad bloating.”
4/5“I use Visbiome and it works really well.”
4/5“My doctor turned me on to one called VSL#3 DS.”
4/5 Bloating & gasRegularity“Visbiome gives me GREAT bm's, but after a few days I get very bloated and stop taking it.”
4/5“Also recommended that when I do start them again, to try VisBiome.”
4/5“Look into Visbiome. It’s helped me through some stomach issue in the past, including right now. It has to be refrigerated, but it’s the only one I’ve found that actually does anything noticeable.”
These are examples of High-potency multi-strain (VSL#3 / Visbiome) products sold on Amazon. They are not ranked by Reddit and the score above is for the ingredient, not a specific product. Check the label for dose and other ingredients.
Published studies (we list them so you can read the evidence yourself; inclusion is not an endorsement):
Across 70 Reddit comments from people who say they have used it, 28 of 31 rated comments were positive and 2 negative, for a GutVerdict score of 3.7/5. These are self-reported experiences, not clinical evidence.
5 of 31 rated owner comments (16%) describe an unwanted effect such as gas, bloating or an upset stomach. Check the safety notes on this page and ask a doctor or pharmacist before starting.
Most rated owner comments come from people in r/SIBO and others who mention SIBO (10 comments, 8 positive).
No. The score summarizes Reddit owner comments only. Factual statements on this page link to NIH or PubMed sources, and nothing here is medical advice.
“I started taking spore based probiotics lately because it's supposed to help with the health of the valve and it do believe it is helping.”
What owners report →
“I've tolerated taking Florastor 3x a day during antibiotics.”
What owners report →
“One one of probiotics I was taking, LGG get rid of bilophila, but increased desulfovibrio.”
What owners report →Last updated 2026-11-03. Mentions scanned: 195 in 170 threads.