Medical disclaimer: GutVerdict summarizes what people say about supplements on Reddit. It is not medical advice, and nothing here is meant to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Talk to your doctor or pharmacist before starting a supplement, especially if you are pregnant, take medicines, or have a medical condition. New, severe or worsening symptoms (such as blood in the stool, weight loss, fever, or night-time symptoms) need a doctor, not a supplement. Full disclaimer.

Supplements for SIBO: What Reddit Users Report

This ranking reflects what people in r/SIBO and others who mention SIBO report in Reddit comments: 1921 rated owner comments, ranked by a context rating that shrinks small samples toward the average. It is not a recommendation to try any of them. Persistent or severe symptoms need a doctor's assessment.

#	Supplement	Context rating	Rated comments here	Positive	Negative	Overall score
1	Seed DS-01	4.0	3	3	0	3.7
2	Magnesium oxide	3.9	36	31	4	4.0
3	Iberogast (STW 5)	3.9	40	37	3	3.8
4	DGL licorice	3.9	14	13	0	3.7
5	L. rhamnosus GG (Culturelle)	3.8	7	7	0	3.9
6	Marshmallow root	3.8	5	5	0	3.5
7	Ginger supplements	3.8	137	113	15	4.1
8	Acacia fiber	3.8	7	6	1	3.8
9	Alpha-galactosidase (Beano)	3.8	7	6	1	3.8
10	Magnesium glycinate	3.7	44	38	5	3.7
11	Butyrate / tributyrin	3.7	49	42	4	3.9
12	Spore-based probiotics (Bacillus)	3.7	38	30	7	4.2
13	Digestive enzymes	3.7	192	149	31	4.3
14	Magnesium citrate	3.7	95	76	13	4.0
15	L. reuteri	3.7	81	64	14	3.5
16	High-potency multi-strain (VSL#3 / Visbiome)	3.7	10	8	1	3.7
17	Atrantil	3.7	76	58	14	3.8
18	Activated charcoal	3.6	32	25	5	3.7
19	Slippery elm	3.6	18	15	2	3.7
20	Saccharomyces boulardii	3.6	87	65	16	4.0
21	PHGG (Sunfiber)	3.6	137	107	25	3.9
22	L-glutamine	3.5	88	63	20	4.0
23	Zinc carnosine	3.5	25	18	6	3.7
24	Bovine colostrum	3.5	21	16	5	3.6
25	Candibactin-AR / BR	3.4	40	27	12	3.5
26	Peppermint oil capsules	3.4	28	20	8	3.8
27	Psyllium husk	3.4	86	59	22	4.2
28	Allicin (Allimed / Allimax)	3.4	141	94	36	3.6
29	Oregano oil	3.3	163	109	47	3.8
30	Berberine	3.3	170	107	54	3.6
31	B. longum 35624 (Align)	3.3	17	10	6	3.4
32	Akkermansia (Pendulum)	3.2	8	5	3	3.3
33	Lactase enzyme	3.2	4	1	2	3.7
34	Inulin / FOS	3.1	13	7	6	3.5

Our safety notes for gut supplements cite NIH sources. For quick shortlists by symptom, see which gut supplements IBS communities rate highest. Unsure where to begin? See how to narrow down gut supplements.

In their words

4/5 Side effects
“For me it was first bifidobacterium probiotic strains that made me feel a lot better (SEED probiotic specifically) but after a while that wouldn't work anymore, then I started taking some random ones I found in a pharmacy, yogurt made me…”

owner comment via r/SIBO · 2026-08-22 · 1 upvotes

4/5 Cost
“All you need is a magnesium oxide powder for a bowel flush tbh.”

owner comment via r/SIBO · 2025-12-16 · 4 upvotes

4/5
“Allison Siebecker's SIBO guidelines, the recommended Iberogast dosage to act as a prokinetic (specifically for the migrating motor complex at night) is **60 drops at bedtime on an empty stomach**...(I think she actually gives it as a range of 30-60)”

owner comment via r/SIBO · 2026-09-29 · 5 upvotes

4/5
“It likely went on to further damage the cells of the stomach and lower acid production even if you are no longer infected and obviously i can't guarantee that without testing but taking betaine hcl as a mock stomach acid, DGL and…”

owner comment via r/SIBO · 2026-01-19 · 1 upvotes

Mixed and negative reports

2/5
“Same only don't have mag oxide or citrate,I have SIBO but stray off diet sometimes, using brewed ginger, I feel it moving a bit but not much comes out, hard time walking because of back & leg problems due to back.”

owner comment via r/SIBO · 2025-11-18 · 1 upvotes

2/5
“We saw tons of specialists, tons of tests, we tried antibiotics and herbals and motility stuff like iberogast.”

owner comment via r/SIBO · 2026-05-26 · 10 upvotes

Before you try anything

Start one supplement at a time so you can tell what made a difference.
Check interactions with any medicine you take: safety and interactions guide.
Background reading: Gut Supplement Safety and Interactions.