Gut-lining & amino acids
Butyrate / tributyrin
3.9 (197 owner comments)
Bloating & gasRegularity
“Also one that helped me butyrate in form of tributrin”
What owners report →Medical disclaimer: GutVerdict summarizes what people say about supplements on Reddit. It is not medical advice, and nothing here is meant to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Talk to your doctor or pharmacist before starting a supplement, especially if you are pregnant, take medicines, or have a medical condition. New, severe or worsening symptoms (such as blood in the stool, weight loss, fever, or night-time symptoms) need a doctor, not a supplement. Full disclaimer.
Gut-lining & amino acids · powder or capsules
L-glutamine: What People With IBS Report on Reddit
Illustration, not a product photo.
An amino acid that is a main fuel for cells lining the intestine.
4.0 GutVerdict score
456 owner comments (168 with a clear rating) from r/SIBO, r/Microbiome, r/IBS, r/Supplements, r/Constipation, November 2025 to October 2026. Top 20% of the 36 rated supplements.
Owner sentiment3.6
Recommendations3.6
Tolerability4.7
ValueNot rated
Value is not rated: the example products differ too much in dose to compare cost fairly. How we score.
The short version
L-glutamine is rated about average among the supplements we track: 4.0/5. Of 168 rated owner comments, 129 were positive, 13 mixed and 26 negative; 15 mention an unwanted effect. People talk most about bloating & gas and side effects.
Reddit comments are self-reported and unverified. They tell you what people noticed, not whether a supplement works or is safe for you.
See what owners report about gut supplements for antibiotics. See what owners report about gut supplements for constipation. See what owners report about gut supplements for cramping.
What it is
- A 2019 randomized trial tested glutamine supplements in people with IBS that began after a gut infection.[PubMed]
Safety and interactions
- Tell your doctor about any supplement you take, especially if you have a chronic illness or take prescription medicines.[NIH Office of Dietary Supplements]
Supplements can interact with medicines. Talk to a doctor or pharmacist first, especially if you are pregnant, take prescription medicine, or have red-flag symptoms. See supplement safety and interactions.
Reports by symptom
| Context | Rated owner comments | Positive | Negative | Unwanted effects |
|---|---|---|---|---|
| SIBO | 88 | 63 | 20 | 8 |
| Bloating & gas | 26 | 19 | 3 | 2 |
| IBS-D & loose stools | 22 | 18 | 2 | 1 |
| IBS-C & constipation | 21 | 15 | 4 | 2 |
| After antibiotics | 16 | 12 | 3 | 1 |
| Pain & cramping | 13 | 8 | 2 | 2 |
| Stool form | 3 | 3 | 0 | 0 |
What Reddit owners say
Commonly praised
- Bloating & gas: 12 owner comments
- Pain & cramping: 6 owner comments
- Regularity: 5 owner comments
Common complaints
- Side effects: 11 owner comments
- Urgency & loose stools: 2 owner comments
- Bloating & gas: 2 owner comments
4/5“My condition improved when I started to take Glutamine in the morning and one banana before bed.”
4/5“L glutamine is good but it can be hit or miss for people with overgrowths, instead i'd focus on other tools for the gut lining like zinc l carnosine, quercetin, boswellia and a few others,”
4/5“L-glutamine has helped me with sugar cravings and I do a scoop per day in water.”
2/5 Side effects“Repair phase was GI revive but something in it gave me heartburn and nausea, so now I do the zinc carnosine and straight glutamine and it's been working well.”
2/5“I had to stop L-glutamine because my body started to have a super high HR as I titrate up.”
+30 more owner comments
4/5“I was so backed up) made me go until lglutamine entered my system.”
4/5 Bloating & gas“So the first time I took L-glutamine I was on a low fodamap diet but still bloating while eating anything.”
4/5 Regularity“My diet has always been good, but I cut out all coffee and alcohol (not a big drinker anyway), starting focusing on better sleep and lots of walking (especially after meals), supplements that were anti-inflammatory like L-Glutamine,…”
4/5“I have found that taking l-glutamine helps me to be less sensitive to things but doesn’t wholly fix my issues and I still have to be careful with what I eat”
4/5“It's been a while since I used L-glutamine free-form powder, but I still have some.”
4/5 Cost“Ive heard glutamine is really good for bowel disorders google suggested it to me after I started researching leaky gut .”
2/5“I was already struggling with anxiety so it was harder to recognize glutamine as being an issue, but the last day I took it I felt like I almost blacked out and then my heart started racing like NASCAR.”
4/5 Regularity“L-Glutamine has helped my bowels become more regular again.”
4/5“Lately, I've been feeling a bit better by taking Astralagus extract, black goat extract, L-glutamine, Kidney supplements, Zinc carnosine.”
4/5 Stopped working“I’ve also seen a functional medicine one doctor and taken various supplements with varied reactions, glutamine made my blood pressure low, a different probiotic helped a little, apples were one of the few things that didn’t bother me to…”
3/5 Side effects“Almost same what I’ve faced, what I can tell you that you have to be very careful of what you are eating, try Low FODMAP, it worked for me doing low fodmap diet for 3 months and taking magnesium glycinate daily at night + glutamine 5 g…”
4/5“if you’re worried about l glutamine maybe look into holistic gut supports like probiotics or postbiotics that help balance things naturally some blends like the flora biome from triquetra health combine multiple strains with prebiotics so…”
4/5“L-glutamine has been an absolute miracle supplement for me, I take 5 G morning and 5 G night both on an empty stomach and then don't eat for at least an hour, I also take a vitamin with active B6 so it can convert the glutamine into GABA...”
3/5 Bloating & gasSide effects“It's complicated we knew nothing on the microbiome a few years before it's so complex that i don't think we can be specialist of it as we still doesn't know enough yet, yes of course as i have gastritis post h pylori i take glutamine 15 g…”
1/5“I actually tried glutamine before and it gave me insane anxiety / metal health issues.”
1/5“SlipperyElm is good for the gut my only worry is it coats the gut so it might effect the L Glutamine from being able to work if it can't make contact”
5/5“I drink a glass of 5g L-Glutamine and one teaspoon of Psyllium seed husks every morning on an empty stomach and it has been lifechanging.”
4/5“L-glutamine really helped me too! I’m happy to hear someone who benefited too!”
5/5“Try L-glutamine, people with IBS swear by it.”
4/5“The other product I have used that does seem to help calm the gut down after the elemental etc is something call GI Reset - it has Glutamine a month many other herbs.”
2/5“I’ve tried l-glutamine too early and it gave me weird symptoms.”
4/5 Bloating & gas“I still have SIBO - I started taking l glutamine & zinc carnosine ~6 weeks ago.”
4/5“TLDR: for me it was glutamine + Vit D (+ vit K for improved absorption) + probiotics.”
4/5“I take zinc + l-glutamine + eat a lot of cooked veggies like cooked potatoes + eggs.”
4/5 Regularity“I get constipated too and started taking it with L glutamine and it made me more regular.”
4/5“I also take Great Stacks Gut L-Glutamine ( you can get it on Amazon)”
4/5“But in the meantime, I’d strongly recommend trying zinc L-carnosine x L-glutamine combo for barrier repair and fuel for for epithelial fuel.”
4/5“I use the optinum nutrition glutamine powder in my protein shakes and have noticed an improvement I bet sauerkraut would be really good too”
4/5“L glutamine has helped me, maybe research it and give it a try.”
4/5“L- Glutamine is great for me, I take it daily and have conquered my gut issues, many times.”
Example products
These are examples of L-glutamine products sold on Amazon. They are not ranked by Reddit and the score above is for the ingredient, not a specific product. Check the label for dose and other ingredients.
Example product · not Reddit-scored
Pure Encapsulations L-Glutamine Powder, 8 Ounces
$55.00 on Amazon (price as of 2026-11-03). Prices change; check Amazon for the current price.
Example product · not Reddit-scored
Now Sports, L-Glutamine Powder, Amino Acid
$19.99 on Amazon (price as of 2026-11-03). Prices change; check Amazon for the current price.
Example product · not Reddit-scored
Nutricost L-Glutamine Powder 1 KG, Unflavored, Non-GMO
$29.95 on Amazon (price as of 2026-11-03). Prices change; check Amazon for the current price.
Research to read
Published studies (we list them so you can read the evidence yourself; inclusion is not an endorsement):
FAQ
What do people with IBS say about L-glutamine on Reddit?
Across 456 Reddit comments from people who say they have used it, 129 of 168 rated comments were positive and 26 negative, for a GutVerdict score of 4.0/5. These are self-reported experiences, not clinical evidence.
Do people report side effects with L-glutamine?
15 of 168 rated owner comments (9%) describe an unwanted effect such as gas, bloating or an upset stomach. Check the safety notes on this page and ask a doctor or pharmacist before starting.
Who talks about L-glutamine most?
Most rated owner comments come from people in r/SIBO and others who mention SIBO (88 comments, 63 positive).
Is L-glutamine scored on clinical evidence?
No. The score summarizes Reddit owner comments only. Factual statements on this page link to NIH or PubMed sources, and nothing here is medical advice.
Related supplements
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Zinc carnosine
3.7 (108 owner comments)
Side effectsFast-acting
“Yes...zinc carnosine has been a gamechanger for me.”
What owners report →
Gut-lining & amino acids
DGL licorice
3.7 (77 owner comments)
Side effectsBloating & gas
“Those were a game changer that pure one with the DGL plus that one took the pain away but you gotta eat right basically plain it sucks.”
What owners report →Comparisons: L-glutamine vs Bovine colostrum
Last updated 2026-11-03. Mentions scanned: 1685 in 1014 threads.