Gut-lining & amino acids
L-glutamine
4.0 (456 owner comments)
Bloating & gasSide effects
“My condition improved when I started to take Glutamine in the morning and one banana before bed.”
What owners report →Medical disclaimer: GutVerdict summarizes what people say about supplements on Reddit. It is not medical advice, and nothing here is meant to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Talk to your doctor or pharmacist before starting a supplement, especially if you are pregnant, take medicines, or have a medical condition. New, severe or worsening symptoms (such as blood in the stool, weight loss, fever, or night-time symptoms) need a doctor, not a supplement. Full disclaimer.
Gut-lining & amino acids · capsules
Butyrate / tributyrin: What People With IBS Report on Reddit
Illustration, not a product photo.
A short-chain fatty acid made by gut bacteria from fiber; sold as butyrate salts or tributyrin.
3.9 GutVerdict score
197 owner comments (89 with a clear rating) from r/SIBO, r/Microbiome, r/IBS, r/Constipation, r/Supplements, November 2025 to October 2026. Top 31% of the 36 rated supplements.
Owner sentiment3.7
Recommendations2.7
Tolerability4.8
ValueNot rated
Value is not rated: the example products differ too much in dose to compare cost fairly. How we score.
The short version
Butyrate / tributyrin is rated about average among the supplements we track: 3.9/5. Of 89 rated owner comments, 77 were positive, 3 mixed and 9 negative; 5 mention an unwanted effect. People talk most about bloating & gas and regularity.
Reddit comments are self-reported and unverified. They tell you what people noticed, not whether a supplement works or is safe for you.
People also compare supplements for IBS-C and constipation on Reddit. There is a separate ranking of what people with bloating and gas rate highest. See what owners report about gut supplements for loose stools.
What it is
- Butyrate is made by gut bacteria when they ferment fiber; supplement trials in IBS are few and small.[PubMed]
Safety and interactions
- Trials are small, so long-term safety is not well known; tell your doctor about any supplement you take.[NIH Office of Dietary Supplements]
Supplements can interact with medicines. Talk to a doctor or pharmacist first, especially if you are pregnant, take prescription medicine, or have red-flag symptoms. See supplement safety and interactions.
Reports by symptom
| Context | Rated owner comments | Positive | Negative | Unwanted effects |
|---|---|---|---|---|
| SIBO | 49 | 42 | 4 | 4 |
| Bloating & gas | 16 | 13 | 2 | 2 |
| IBS-C & constipation | 11 | 9 | 2 | 1 |
| Pain & cramping | 7 | 7 | 0 | 1 |
| After antibiotics | 6 | 6 | 0 | 1 |
| IBS-D & loose stools | 5 | 5 | 0 | 0 |
What Reddit owners say
Commonly praised
- Bloating & gas: 6 owner comments
- Regularity: 4 owner comments
- Taste & texture: 3 owner comments
Common complaints
- Side effects: 5 owner comments
- Bloating & gas: 1 owner comment
- Regularity: 1 owner comment
- Stopped working: 1 owner comment
4/5“Also one that helped me butyrate in form of tributrin”
4/5 Taste & texture“- a lot of head issus can be due to leaky gut (try something lile butyrate) and possibly due to histamine reactions; taking DAO (an enzyme that dissolves histamine) was the one single thing that helped me the most”
4/5 Stool form“I do not have experience with Citrobacter, but know that resistant starch, the largest natural source of prebiotic fiber in the historical diet, remodels the entire microbiome and specifically increases butyrate more than other types of prebiotic fibers.”
2/5 Regularity“I have Crohn's disease, I've tried all kinds of probiotics with no effect but akkermansia muciniphilia and butyrate (postbiotic) have an unmistakable positive effect on my bms.”
2/5 Side effects“It may be a side effect of your bowels producing butyrate.”
+30 more owner comments
4/5 Regularity“I take Tributyrin, pro butyrate and regular sodium butyrate just to cover my bases in case one form is more effective for me.”
4/5“Adding sodium Butyrate really helped me with the lining of my gut.”
4/5“The biggest direct improvement for my leaky gut was sodium butyrate.”
4/5“3) to improve your quality of life I would suggest trying DAO enzymes (helps with braking down histamine) and butyrate (helps with leaking gut); histamine and leaky gut ka responsible for you feeling like shit and this should help; it made…”
4/5“while healthy fats (like ghee/mct) are great for the gut lining (butyrate), they trigger the 'ileal brake' which slows motility.”
4/5 Taste & texture“Arabinoxylan sources are great, but oat tend to break down before the large intestine where most of the anaerobic butyrate producing keystone taxa lives, this is why we need resistant fibers and starch..”
4/5“The fact that Butyrate directly impacts the gut and cause changes which could easily affect one's physical and emotional health.”
4/5“I have seen some people report significant improvement with use of tributyrin though.”
4/5“Taking tributyrin helped me so much with my gut!”
4/5“I've been taking sodium butyrate for a few weeks now.”
4/5 Bloating & gas“I had very low butyrate levels so I will be doing the Microbiome Labs prebiotic fiber as well (start low on this stuff too, it can cause serious gas).”
4/5“It has been some time since I tried butyrate.”
4/5“Also, see about gradually increasing your butyrate levels via pills and diet.”
2/5“I was like this so I stopped taking probiotics and ate high fiber foods to feed butyrate producing bacteria to help the gut lining and low sugar, nothing processed especially beans as butyrate producing bacteria feed on the polyphenols in beans.”
1/5“I forgot to add, that taking either boulardii or butyrate in fiber heavy meals made it so much worse.”
4/5“After talking to several doctors I got an advice that worked for me - stop taking everyting you take and JUST go for some DAO supplement (like DAOpro) and sodium butyrate.”
4/5“Try l reuteri biogaia for sleep if you need more sleep support try yakult probiotic drink that helps with sleep too , then try too get blackberries,blueberries and a green banana in your diet too boost beneficial bacteria and butyrate (I…”
4/5“Sodium butyrate was surprisingly effective for me, even though I tried nac and bromelain before.”
4/5 Bloating & gas“I take 2 capsules (total of 1200 mg Butyric Acid) Sodium Butyrate by BodyBio.”
3/5“I had horrible SIBO and what helped me the most has been a combined, slow, approach of lowering guts inflammation with Tributyrin (specific form, not Butyrate) and trying to live in a parasympathetic state as much as I could (not just…”
4/5“I feel better taking a B complex liquid vitamin and also butyrate.”
4/5 Stool form“I also added butyrate around the same time I switched to a better probiotic and stool consistency improved a lot within two weeks.”
2/5 Side effects“I was trying to experiment it on myself but could not get Tributyrin.”
4/5“For the rebuild phase after, a probiotic w/ butyrate and strict meal spacing for the MMC is what worked for me.”
4/5 Pain & cramping“I also took l glutamine first thing and sodium butyrate helps with intestinal pain.”
4/5“The only thing that has helped me is sodium butyrate & digestive enzymes.”
4/5“I discovered Akkermansia single strain, Butyrate (single strain) & Rituals 3-1 Probiotics (3 strains).”
4/5“A few things that are helping me are r-alpha lipoic acid, pure encapsulations brand of l glutamine and Healus brand of tributyrin.”
4/5 Cost“Sodium butyrate significantly helped my gut, but more noticeably my skin.”
5/5 Bloating & gas“In the supplement form is called sodium butyrate but theres also magnesium/calcium butyrate.”
Example products
These are examples of Butyrate / tributyrin products sold on Amazon. They are not ranked by Reddit and the score above is for the ingredient, not a specific product. Check the label for dose and other ingredients.
Example product · not Reddit-scored
Designs for Health Tri-Butyrin Supreme, Gut Health, 60 Softgels
$53.49 on Amazon (price as of 2026-11-03). Prices change; check Amazon for the current price.
Example product · not Reddit-scored
Healthy Gut Tributyrin-X, Bioavailable Butyrate Supplement, 90 Servings
$79.99 on Amazon (price as of 2026-11-03). Prices change; check Amazon for the current price.
Research to read
Published studies (we list them so you can read the evidence yourself; inclusion is not an endorsement):
FAQ
What do people with IBS say about Butyrate / tributyrin on Reddit?
Across 197 Reddit comments from people who say they have used it, 77 of 89 rated comments were positive and 9 negative, for a GutVerdict score of 3.9/5. These are self-reported experiences, not clinical evidence.
Do people report side effects with Butyrate / tributyrin?
5 of 89 rated owner comments (6%) describe an unwanted effect such as gas, bloating or an upset stomach. Check the safety notes on this page and ask a doctor or pharmacist before starting.
Who talks about Butyrate / tributyrin most?
Most rated owner comments come from people in r/SIBO and others who mention SIBO (49 comments, 42 positive).
Is Butyrate / tributyrin scored on clinical evidence?
No. The score summarizes Reddit owner comments only. Factual statements on this page link to NIH or PubMed sources, and nothing here is medical advice.
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What owners report →Last updated 2026-11-03. Mentions scanned: 1176 in 673 threads.